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10% off your first order
Every lot ships with a public COA
Order by 2pm ET on weekdays, ships the same day
Save up to 20% with volume pricing
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Research peptide
Cibinetide · EPO-derived innate repair receptor agonist peptide
$49.99
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SKU: ARA290-10
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For research use only. Not for human consumption.
Technical specifications
Molecular profile
ARA-290 (INN: cibinetide) is a synthetic linear 11-amino-acid peptide, pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser, designed from the aqueous face of helix B of erythropoietin (EPO). The N-terminal residue is cyclised to pyroglutamate, and the peptide is also described in the literature as pyroglutamate helix B surface peptide (pHBSP).
ARA-290 was engineered to lack the erythropoietic activity of EPO while engaging the so-called innate repair receptor, a proposed heteromeric complex of the EPO receptor and the β-common receptor (CD131). Published studies have examined its tissue-protective and anti-inflammatory signalling in rodent models of ischaemic and inflammatory tissue injury, and its effects on mechanical allodynia in rat nerve-injury models and in β-common receptor knockout mice.
Supplied as a lyophilized powder in a sealed vial.
For laboratory research use only. Not for human or veterinary use.
Storage requirements
Handling
Literature
2 publications for further reading. Cited for scientific context only.
Proc Natl Acad Sci U S A · 2008
Brines M, Patel NSA, Villa P, et al.
Anesthesiology · 2011
Swartjes M, Morariu A, Niesters M, et al.
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