GHK-Cu (Copper Tripeptide-1)

GHK-Cu (copper tripeptide-1; prezatide copper) is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys, GHK). GHK was originally isolated from human plasma. It binds Cu2+ with high affinity, forming a characteristic blue complex.

GHK-Cu has been examined in fibroblast culture studies, where it was reported to stimulate collagen synthesis and to modulate matrix metalloproteinase expression, and in rodent models of tissue repair and extracellular-matrix remodelling. More recent analyses of gene-expression datasets have reported that GHK is associated with changes in the expression of a large number of human genes, including those related to extracellular-matrix organisation and antioxidant pathways. GHK-Cu is used as a tool compound in research on copper transport and delivery to cells, fibroblast and keratinocyte biology, and extracellular-matrix turnover in vitro and in animal models.

Supplied as a sealed, lot-numbered vial with a lot-matched Certificate of Analysis (HPLC purity and MS identity).

For laboratory research use only. Not for human or veterinary use.