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10% off your first order
Every lot ships with a public COA
Order by 2pm ET on weekdays, ships the same day
Save up to 20% with volume pricing
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Research peptide
NewACTH(4-7)-Pro-Gly-Pro · Synthetic ACTH(4-10) analogue heptapeptide
$49.99
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In stock
SKU: SEMAX-10
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Arrives 2–5 business days after dispatch
2–5 business days in transit after dispatch
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For research use only. Not for human consumption.
Technical specifications
Molecular profile
Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro, in which the adrenocorticotropin fragment ACTH(4-7) is extended at its C-terminus by a Pro-Gly-Pro tripeptide. It was developed as an analogue of the melanocortin fragment ACTH(4-10) (Met-Glu-His-Phe-Arg-Trp-Gly), with the C-terminal Arg-Trp-Gly replaced by Pro-Gly-Pro.
Published work has compared the enzymatic stability of Semax with that of ACTH(4-10), including studies of N-terminal degradation by rat blood enzymes. In neurochemical research, Semax has been investigated for its effects on brain-derived neurotrophic factor (BDNF) and its receptor TrkB, with altered expression reported in the rat hippocampus, and it has been studied in vitro as an inhibitor of enkephalin-degrading enzymes in serum. It is used in rodent studies of melanocortin-related peptide signalling, neurotrophin regulation and peptide metabolism.
Supplied as a sealed, lot-numbered vial with a lot-matched Certificate of Analysis (HPLC purity and MS identity).
For laboratory research use only. Not for human or veterinary use.
Earn 49 points with this purchase
Storage requirements
Handling
Literature
2 publications for further reading. Cited for scientific context only.
Biochemical and Biophysical Research Communications · 1991
Potaman VN, Alfeeva LY, Kamensky AA, et al.
Brain Research · 2006
Dolotov OV, Karpenko EA, Inozemtseva LS, et al.
Verified test results
Each lot is analysed by Independent Analytical Lab (example) (ISO/IEC 17025 accredited) before release. This is the report for the current lot, as published by the lab.
Independent Analytical Lab (example)
ISO/IEC 17025 accredited
99.89%
Purity by HPLC
Full QC panel
5 passed · 2 reported| Assay | Result | Status |
|---|---|---|
| AppearanceVisualWhite lyophilized powder | White lyophilized powder | Pass |
| PurityHPLC · UV 214 nm99.89% | 99.89% | Pass |
| IdentityESI-MSConforms | Conforms | Pass |
| Net peptide contentElemental analysis85.0% | 85.0% | Reported |
| Water contentKarl Fischer2.8% | 2.8% | Reported |
| EndotoxinLAL, kinetic< 0.5 EU/mg | < 0.5 EU/mg | Pass |
| Heavy metalsICP-MSNot detected | Not detected | Pass |
Open any lot’s report, or look up the lot number printed on your vial label.
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